OPRD Article from Merck on Palladium Removal 01/05/2012
Interesting and novel approach is outlined in a recent OPRD article from Merck http://pubs.acs.org/doi/abs/10.1021/op2001657 Screening Binary Systems of Chelating Agents Combined with Carbon or Silica Gel Adsorbents: The Development of a Cost-Effective Method to Remove Palladium from Pharmaceutical Intermediates and APIs by Lijun Wang The approach is certainly worth considering on small scale. Basically, they are using homogeneous chelating agents to capture to metal and then adsorbing this onto a solid surface for filtration. They note, this approach could be economical on scale, especially considering many commercially available scavengers cost $1000's/kg at scale. We agree - one of the main issues on silica is high cost, especially considering silica unlike ion exchange resins has relatively low loading so a lot of it is potentially needed. One of the benefits of the PhosphonicS technology is it is one step with a very low cost of manufacture enabling competitve pricing below $1000/kg for bulk orders. Not quite as low as offered by this Merck approach, but also the Merck approach requires more effort in terms of processing and development. So overall probably equal. CommentsLeave a Reply |
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