- Additional information
- Case Studies
SPM32 is the gold standard scavenger designed to effectively and efficiently remove platinum group metals from APIs at any stage of development or commercialisation . The incorporation of thiol ligands means that SPM32 has a very high affinity for platinum group metals.
It is first choice scavenger for purification and the ubiquitous recommendation for Pd removal. It also has a high affinity for Rh, Ru, Ir and Au but will remove a wide range of other metals including Cu.
Au, Cu, Ir, Pd, Ru
Ag, Cd, Fe, Hg, Ni, Os, Pb, Pt, Sn
An API contained >100 ppm Pd from a Pd-catalysed coupling reaction performed at the final stage of the syntheic process. Treatment of the crude sample in an organic-aqueous solvent mixture at >80 degrees C with SPM32 remduced the Pd to <5 ppm.
An API contained 1500 ppm Ru following transfer hydrogenation. Treatment of a solution of product in acetonitrile at 55 degrees C as a batch slurry for 1 hour with SPM32 removed the Ru to 4 ppm.