Palladium removal after a Suzuki coupling reaction
Stream1000 ppm PdPost Suzuki reaction
Result4 ppm PdAfter slurry batch treatment, no loss of API product
Applications
Superior Purification: Removing PGMs to Achieve Compliance
Regulatory bodies require pharmaceutical manufacturers to demonstrate that residual metal catalysts in APIs and drug products fall below strict permitted daily exposure limits. At these trace concentrations, generic scavengers often fall short. Our highly functionalised scavengers are designed to target residual metal contaminants, helping manufacturers achieve ICH Q3D compliance with confidence.
Superior Purification
Increased Speed to Market
Our high-performance scavengers reduce the time needed to achieve metal specification compliance, helping you move from development through to commercialisation faster.
Meet and Exceed Regulatory Requirements
Our functionalised silica products extract unwanted metal species from your APIs so you consistently meet or exceed ICH Q3D and other regulatory requirements.
Fully Scalable
The same scavenger chemistry proven in your laboratory screen scales directly to pilot and full production without redevelopment.
What Makes PhosphonicS Unique?
Patented Multiple Chelating Site Technology
PhosphonicS uses patented technology for attaching powerful ligands to a silica backbone. The ability to incorporate multiple chelating sites enables our products to outperform other solid supported products at every concentration of metal in your stream.
Superior Results Across a Wide Range of APIs
Consistently superior results have been demonstrated across a broad range of pharmaceutical APIs, from early stage research through to full scale manufacturing.
Higher Product Yields
Our selective chemistry targets the metal, not the product, delivering higher yields from your purification process without compromising API activity or purity.
Proven Track Record from Lab to Plant Scale
PhosphonicS scavengers have been proven from SPE cartridges for Med Chem applications through to customised cartridge units for full scale production.
Relevant Products
SPM32
High-capacity scavenger for palladium removal in pharmaceutical streams
SEM26
Selective for platinum group metals in aqueous and organic solvents
MTCf
Removes multiple precious metals simultaneously from complex process solutions
STA3
High-affinity palladium scavenger for organic and mixed solvent pharmaceutical streams
SPA5
Broad-spectrum PGM scavenger for multi-metal pharmaceutical processes
SEA
Selective scavenger for precious metal recovery from acidic process streams
POH1
Designed for recovery of homogeneous PGM catalysts from aqueous chemical processes
Not sure which product is right for your process?
Explore the PhASE ProgrammeReal Results
From Pharmaceutical Applications
Palladium removal after a late-stage Suzuki coupling reaction
Stream110 ppm PdPost late-stage Suzuki reaction
Result1.3 ppm PdFixed bed treatment after crystallisation
Ru removal from an oncology target molecule
Stream1,500 ppm RuMulti-kilogram batches
Result4 ppm Ru
Slurry mode · >99.5% Ru removal
Cu removal from an indazole intermediate
Stream875 ppm CuLab scale
Result8 ppm Cu99% Cu removal
Slurry mode, MeCN
Pd-catalysed alpha-arylation
Stream600 ppm PdToluene
Result<10 ppm PdHigh product yield
Plant scale
Related Resources
Brochure
Pharmaceutical & Electronics Recovery
Overview of PhosphonicS recovery scavengers for process and waste streams, covering approaches to recover value from traces of precious metals in pharmaceutical and electronics manufacturing.
Download PDFTechnical Details
Pharmaceutical & Electronics Recovery
Technical data on PhosphonicS recovery scavengers for pharmaceutical and electronics process streams.
Download PDFReady to solve your palladium removal challenge?
Submit an enquiry or explore the PhASE programme to find the optimum solution for your specific process.