Publications
The science behind the technology
PhosphonicS maintains an active publication record across journal articles, patents, and white papers. Our published work demonstrates the depth of scientific expertise behind every product we make.
26
Journal Articles
13
Patents
Journal Articles
Peer-reviewed research
Our scientists publish regularly in leading chemistry and materials journals. The articles below represent a selection of published work underpinning PhosphonicS technology.
Showing 26 publications. For access to full texts or supporting data, contact us at sales@phosphonics.com.
Org. Process Res. Dev.
Palladium Extraction Following Metal-Catalyzed Reactions: Recent Advances and Applications in the Pharmaceutical Industry
Economidou, Marina; Mistry, Nisha; Wheelhouse, Katherine M. P.; Lindsay, David M.
Org. Process Res. Dev. 2023, 27, 1585-1615
Organic Process Research and Development
Development of a Synthesis of Kinase Inhibitor AKN028
Bremberg, Ulf; Eriksson-Bajtner, Johan; Lehmann, Fredrik; Oltner, Viveca; Solver, Ellen; Wennerberg, Johan
Org. Process Res. Dev. 2018, 22(10), 1360-1364
Organic Process Research and Development
Statistical DoE Approach to the Removal of Palladium from Active Pharmaceutical Ingredients (APIs) by Functionalized Silica Adsorbents
Recho, Jan; Black, Richard J. G.; North, Christopher; Ward, James E.; Wilkes, Robin D.
Organic Process Research and Development (2014), 18(5), 626-635.
Topics in Organometallic Chemistry, Springer
Meeting metal limits in Pharmaceutical processes
Forfar, Laura C.; Murray, Paul M.
In: Colacot T., Sivakumar V. (eds) Organometallics in Process Chemistry. Topics in Organometallic Chemistry, vol 65. Springer, Cham. 2019, pp 217-252.
BioMed Research International
Alkyl Thiourea Functionalised Silica for the Effective Removal of Heavy Metals from Acanthopanax senticosus Extract
Guo Hong-Li; Zhang Min; Meng Xiao-Xia; Gao Xiu-Li; North Christopher et al.
BioMed Research International (2020), 2020, 9860425
ACS National Meeting
Metal removal from discovery to commercialisation: scaling up your scavenger
Purser, Sophie; Blanco, Ana; Murray, Paul
Abstracts of Papers, 251st ACS National Meeting, San Diego, CA, March 2016, CATL-295.
ACS National Meeting
Smartest silica technology: Getting the most from your Pd-catalysed process
Purser, Sophie; North, Christopher; Murray, Paul
Abstracts of Papers, 251st ACS National Meeting, San Diego, CA, March 2016, CATL-453.
Hydrocarbon Engineering
Too precious to waste
Astles, David
Hydrocarbon Engineering (2011), 16(12), 27-31.
Organic Process Research and Development
Scaling up Metal Scavenging Operations for Pharmaceutical Pilot Plant Manufactures
Reginato, Gloriana; Sadler, Paul; Wilkes, Robin D.
Org. Process Res. Dev. 2011, 15(6), 1396-1405.
Tetrahedron Letters
New functionalized silicas for highly selective cation exchange SPE purification in medicinal chemistry
Brown, Jane; Chighine, Alessandra; Colucci, Marie A.; Galaffu, Nicola; Hirst, Simon C.; Seymour, Helen M.; Shiers, Jason J.; Wilkes, Robin D.; Williams, Jonathan G.; Wilson, John R. H.
Tetrahedron Letters (2008), 49(33), 4968-4971.
Journal of Molecular Catalysis A: Chemical
Silicaethylphosphatrioxaadamantane: A new support for palladium catalysts and evaluation in Suzuki coupling reactions
Guino, Meritxell; Sullivan, Alice C.; Wilson, John R. H.
Journal of Molecular Catalysis A: Chemical (2008), 293(1-2), 25-30.
Journal of Molecular Catalysis A: Chemical
Covalently linked ethylmercaptophenyl sulfonic acid and ethylmercaptobenzyl sulfonic acid silica materials: Synthesis and catalytic activity
Bugrayev, A.; Al-Haq, N.; Okopie, R. A.; Qazi, A.; Suggate, M.; Sullivan, A. C.; Wilson, J. R. H.
J. Mol. Catal. A: Chem. 2008, 280, 96-101.
Journal of Molecular Catalysis A: Chemical
Dithio palladium modified silicas: New heterogeneous catalysts for Suzuki cross-coupling reactions
Al-Hashimi, M.; Qazi, A.; Sullivan, A. C.; Wilson, J. R. H.
J. Mol. Catal. A: Chem. 2007, 278, 160-164.
Journal of Molecular Catalysis A: Chemical
Palladium ethylthioglycolate modified silica: a new heterogeneous catalyst for Suzuki and Heck cross-coupling reactions
Al-Hashimi, M.; Sullivan, A. C.; Wilson, J. R. H.
J. Mol. Catal. A: Chem. 2007, 273, 298-302.
Organic Process Research and Development
Highly Functionalized Sulfur-Based Silica Scavengers for the Efficient Removal of Palladium Species from Active Pharmaceutical Ingredients
Galaffu, Nicola; Man, Siud Pui; Wilkes, Robin D.; Wilson, John R. H.
Organic Process Research and Development (2007), 11(3), 406-413.
Innovations in Pharmaceutical Technology
Functionalised silicas: addressing the industrial and environmental challenges of API synthesis
Wilson, John; Wilkes, Robin
Innovations in Pharmaceutical Technology (2007), (22), 86-89.
Hydrocarbon Engineering
Metal scavengers
Astles, David M.; Beirne, Kevin M.
Hydrocarbon Engineering (2007), 12(12), 93-96.
Chimica Oggi
Novel heterogeneous metal oxidation catalysts: environmentally friendly catalysts for laboratory to process scale applications
Wilkes, Robin D.; Wilson, John R. H.
Chimica Oggi (2007), 25(4), 22-25.
Speciality Chemicals Magazine
Solid phase catalysts: novel functionalized silicas offering new synthetic methods
Wilson, John; Sullivan, Alice
Speciality Chemicals Magazine (2006), 26(5), 28-30.
Speciality Chemicals Magazine
Immobilisation technology for green chemistry applications
Colman, Robert
Speciality Chemicals Magazine (2007), 27(6), 38-39, 41.
Tetrahedron Letters
Selective oxidations of sulfides to sulfoxides using a silica immobilised vanadyl alkyl phosphonate catalyst
Al-Hashimi, M.; Fisset, E.; Sullivan, A. C.; Wilson, J. R. H.
Tetrahedron Lett. 2006, 47, 8017-8019.
Tetrahedron Letters
Selective oxidations of allylic alcohols using vanadyl and cobalt (II) alkyl phosphonate modified silicas
Jurado-Gonzalez, M.; Sullivan, A. C.; Wilson, J. R. H.
Tetrahedron Lett. 2004, 45, 4465-68.
Tetrahedron Letters
Allylic and benzylic oxidation using cobalt (II) alkyl phosphonate modified silica
Jurado-Gonzalez, M.; Sullivan, A. C.; Wilson, J. R. H.
Tetrahedron Lett. 2003, 44, 4283-86.
Tetrahedron Letters
Oxidation of alcohols using cerium (IV) alkyl phosphonate modified silica
Al-Haq, N.; Sullivan, A. C.; Wilson, J. R. H.
Tetrahedron Lett. 2003, 44, 769-77.
Journal of Materials Chemistry
Synthesis, characterisation and catalytic activity of porous vanadyl phosphonate-modified silicas
Jurado-Gonzalez, M.; Ou, D. L.; Sullivan, A. C.; Wilson, J. R. H.
Journal of Materials Chemistry (2002), 12(12), 3605-3609.
Chemical Communications
A new solid acid catalyst: the first phosphonate and phosphonic acid functionalised microporous polysilsesquioxanes
Jurado-Gonzalez, M.; Ou, D. L.; Ormsby, B.; Sullivan, A. C.; Wilson, J. R. H.
Chem. Commun. 2001, 67-68.
Patents
Proprietary technology, protected
PhosphonicS holds patents covering the core chemistry and manufacturing processes behind our functionalised silica scavengers. Our intellectual property represents two decades of materials science innovation.
Patent
Organopolysiloxanes and use thereof
PCT Int. Appl. WO 2025021964 A1, 2024
Patent
Functionalised polysaccharide compounds
Taylor, Nicholas P.; Forfar, Laura C.; Murray, Paul M.; North, Christopher; Watson, Alexander
PCT Int. Appl. WO 2019101883 A1, 2019.
Patent
Functionalised materials, process for the production and uses thereof
Wilson, John Robert Howe
U.S. Patent US 9290522 B2, 2016.
Patent
Process for the removal and return of a catalyst to a liquid phase medium
Murray, Paul; Wilkes, Robin; North, Christopher
U.S. Pat. Appl. US 20150299229 A1, 2015.
Patent
Functionalized silane-based materials and their use as catalysts
Wilson, John Robert Howe
PCT Int. Appl. WO 2012095307 A1, 2012.
Patent
Substituted organopolysiloxanes and use thereof
Wilson, John Robert Howe; Sullivan, Alice Caroline; Man, Siud Pui
U.S. Patent US 8148562 B2, 2012.
Patent
Functionalized materials especially metal scavengers to extract platinum, rhodium, palladium, ruthenium, iridium, and gold
Wilson, John Robert Howe; Man, Siud Pui
PCT Int. Appl. WO 2011128061 A1, 2011.
Patent
Functionalized organosiloxane-type materials and uses thereof
Wilson, John Robert Howe; Galaffu, Nico; Man, Siud Pui; Wilkes, Robin
PCT Int. Appl. WO 2009049911 A1, 2009.
Patent
Substituted organopolysiloxanes and use thereof
Wilson, John Robert Howe; Sullivan, Alice Caroline; Man, Siud Pui
PCT Int. Appl. WO 2007090676 A1, 2007.
Patent
Substituted organopolysiloxanes containing phosphonic groups, methods for the production and use thereof
Wilson, John Robert Howe; Sullivan, Alice Caroline; Man, Siud Pui
PCT Int. Appl. WO 2007006569 A1, 2007.
Patent
Substituted organopolysiloxanes and use thereof
Wilson, John Robert Howe; Sullivan, Alice Caroline; Man, Siud Pui
PCT Int. Appl. WO 2006013060 A1, 2006.
Patent
Substituted organopolysiloxanes and use thereof
Wilson, John Robert Howe; Sullivan, Alice Caroline; Man, Siud Pui
PCT Int. Appl. WO 2006013080 A1, 2006.
White Paper
In-depth technical reading
White Paper
Process Development White Paper: Metal Scavenging
A comprehensive technical overview of PhosphonicS scavenging technology, covering the chemistry of functionalised silica, application across industries, and process design considerations for scale-up.
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